Duodenal Eosinophilia in Functional Dyspepsia

Aim : to present observation of a patient diagnosed with functional dyspepsia based on current guidelines, and having increased eosinophil counts in the biopsy specimen duodenal mucosa. To consider possible causes eosinophilia light present-day concepts. Highlights . Patient K., 40 years old, complained dyspeptic phenomena, first appearance which she had noted at age 18. The poor tolerance canned fermented foods, provoked an increase sometimes caused watery diarrhea. examination excluded “symptoms concern”. Successful antihelicobacter eradication therapy was carried out. Morphological stomach showed phenomena mild chronic inflammation without intestinal metaplasia or glandular atrophy. A mucosa descending part duodenum moderate levels mononuclears eosinophils its lamina propria penetration into epithelium villi formation clusters. suffers from pollinosis; sensitization birch pollen by skin prick test. However, has no oral allergy symptoms, does not allow linking food allergy. Based dyspepsia. In addition dietary restrictions, treatment courses proton pump inhibitor, itopride, S-methylmethionine sulfonium chloride, antihistamine effect, were recommended for periods worsening Conclusion clinical significance local histamine production patients diagnosis deserves special attention. Triggering factors provoking symptoms should be analyzed; particular, diary exclusion allergies are recommended. Histamine-neutralizing drugs may play role FD future.